The Prevalence of Cervical Human Papillomavirus Infection in Brazilian Amazonia

Presenter: 
Hellen Fuzii, Universidade Federal do Pará, Belém, Brazil

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Abstract: Human papillomaviruses (HPV) are members of the Papillomaviridae family. More than 100 types of HPV have been identified. Some types cause cutaneous infection (common skin wart), whereas others cause mucosal infection. There are ∼40 types that cause mucosal infection. Mucosal HPV types are classified on the basis of their association with cervical cancer. The “low-risk” types of mucosal HPV, known as “nononcogenic”, are associated with anogenital warts and mild cervical dysplasia. The “high-risk” types, also known as “oncogenic,” are associated with anogenital cancers and low- and high-grade dysplasias. Worldwide, cervical cancers are caused by high-risk HPV. The cervical cancer in Brazil is the thirtiest most common in the female population, and represents the second cause of death by cancer in women. Using the established PCR assay with MY09-MY11 primers, we investigated the prevalence of HPV in Brazilian Amazonia. Cervical scrapes were collected from women (age 13 to 78 years old) with normal cytology, and DNA was extracted using the GFX kit (GE healthcare). All volunteers answered an epidemiological questionnaire. Among women from Belém city, an urban area, the prevalence was 15%, and higher in the age of 13 to 25 year age group (19%). In other data, when we analyzed only the adolescents (age 13 to 19 years old) the prevalence goes to 28%. The other urban area, Rio Branco city, the prevalence was 19.7%. The rural women from Tucuruí city showed a prevalence of 14.2%. The differences between these prevalences were associated with socioeconomic factors and sexual behavior, like marital status, number of partners and condom use.  These findings indicate the necessity to elaborate specific strategies to reduce risks to rural and urban women.

About the Presenter: 

Hellen T. Fuzii is a graduate in Pharmacy and Biochemistry from the Oswaldo Cruz College of Pharmaceutical Sciences (1997), and holds a Mfuziiaster’s   degree in Microbiology and Immunology (2000) and a doctoral degree in pediatrics (2005) from the Escola Paulista de Medicina, Universidade Federal de São Paulo. During post-graduate studies, she used molecular and cellular biology techniques to analyze immune responses to cancer and autoimmune disease.    Currently, she is professor of cellular biology at the Universidade Federal do Pará, Tropical Medicine Institute, where she coordinates the Ethics Committee in Human Research.   Research foci include the principal infectious agents of HPV, HTLV, HIV and M. leprea. E-mail: hellenfuzii@gmail.com


Presented on: 
April 21, 2011
Language: 
English
Event: 
Symposium 2011
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